Significant impact of mTORC1 and ATF4 pathways in CHO cell recombinant protein production induced by CDK4/6 inhibitor
Author:
Affiliation:
1. Process Cell Sciences, Biologics Process R&D, Merck & Co., Inc. Kenilworth New Jersey USA
2. Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore Maryland USA
Publisher
Wiley
Subject
Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.28050
Reference79 articles.
1. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism
2. Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2
3. Amino Acid Sensing via General Control Nonderepressible-2 Kinase and Immunological Programming
4. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
5. Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program
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1. Transcriptomics and cell painting analysis reveals molecular and morphological features associated with fed‐batch production performance in CHO recombinant clones;Biotechnology and Bioengineering;2023-08-09
2. A reflection on the improvement of Chinese hamster ovary cell-based bioprocesses through advances in proteomic techniques;Biotechnology Advances;2023-07
3. Cyclin-dependent kinase 6 (CDK6) as a potent regulator of the ovarian primordial-to-primary follicle transition;Frontiers in Cell and Developmental Biology;2022-12-23
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