Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells

Author:

Brew Christine T.,Aronchik Ida,Hsu Jocelyn C.,Sheen Joon-Ho,Dickson Robert B.,Bjeldanes Leonard F.,Firestone Gary L.

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference62 articles.

1. Chemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinol;Grubbs;Anticancer Res,1995

2. Effects of dietary indole-3- carbinol on estradiol metabolism and spontaneous mammary tumors in mice;Bradlow;Carcinogenesis,1991

3. Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles;Wattenberg;Cancer Res,1978

4. Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling;Cover;J Biol Chem,1998

5. Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter;Cram;J Biol Chem,2001

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