Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge-Reference-Cited by-同舟云学术

Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge

Published:2014-04-16 Issue:8 Volume:82 Page:1656-1667
ISSN:0887-3585
Container-title:Proteins: Structure, Function, and Bioinformatics
language:en
Short-container-title:Proteins

Author:

Malia Thomas J.¹,Teplyakov Alexey¹,Brezski Randall J.¹,Luo Jinquan¹,Kinder Michelle¹,Sweet Raymond W.¹,Almagro Juan C.¹,Jordan Robert E.¹,Gilliland Gary L.¹

Affiliation:

1. Biologics Research; Janssen Research and Development; LLC; Spring House Pennsylvania

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/prot.24545/fullpdf

Reference37 articles.

1. The origins, specificity, and potential biological relevance of human anti-IgG hinge autoantibodies;Brezski;ScientificWorldJournal,2011

2. Human anti-IgG1 hinge autoantibodies reconstitute the effector functions of proteolytically inactivated IgGs;Brezski;J Immunol,2008

3. Cleavage of IgGs by proteases associated with invasive diseases: an evasion tactic against host immunity?;Brezski;MAbs,2010

4. A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy;Fan;Breast Cancer Res,2012

5. Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid;Ryan;Mol Immunol,2008

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions;Communications Biology;2022-09-14

2. Proteinase-nicked IgGs: an unanticipated target for tumor immunotherapy;OncoImmunology;2018-07-23

3. Roles of the disulfide bond between the variable and the constant domains of rabbit immunoglobulin kappa chains in thermal stability and affinity;Protein Engineering, Design and Selection;2018-05-30

4. Molecular characterization of human anti-hinge antibodies derived from single-cell cloning of normal human B cells;Journal of Biological Chemistry;2018-01

5. Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities;Scientific Reports;2017-07-19