Aneuploidy in neoplasia: Single‐cell data on 83,862 tumors

Author:

Mertens Fredrik12ORCID,Hofvander Jakob1ORCID,Mandahl Nils1,Mitelman Felix1

Affiliation:

1. Division of Clinical Genetics, Department of Laboratory Medicine Lund University Lund Sweden

2. Department of Clinical Genetics, Pathology, and Molecular Diagnostics Division of Laboratory Medicine Lund Sweden

Abstract

AbstractChromosomal aneuploidy, that is, numerical chromosome aberrations, is one of the molecular hallmarks of cancer. However, when neoplasms are studied with sequencing‐ and array‐based approaches, chromosome numbers and ploidy states are typically inferred from bulk DNA data. Furthermore, published molecular estimates of neoplasia‐associated aneuploidy often also include genomic imbalances resulting from various types of structural rearrangement, which likely result from other mechanisms than numerical chromosome aberrations. We thus analyzed chromosome numbers using single‐cell cytogenetic data from 83,862 tumors, and show that both benign and malignant tumors are highly heterogeneous with regard to deviations from the normal, diploid state. Focusing on the chromosome numbers in 112 specific tumor types, defined by both exact morphologic diagnosis and organ location and from which data from ≥50 cases were available, we found two major clusters: one predominated by near‐diploid neoplasms and one by neoplasms with extensive aneuploidy and one or more whole genome doublings. The former cluster included most benign solid tumors, myeloid neoplasms, and malignant gene fusion‐associated solid tumors, whereas the latter was predominated by malignant solid tumors and lymphomas. For 16 malignant tumor types, the distribution of chromosome numbers could be compared to TCGA ploidy level data. Cytogenetic and molecular data correlated well, but the former indicates a higher level of clonal heterogeneity. The results presented here suggest shared pathogenetic mechanisms in certain tumor types and provide a reference for molecular analyses.

Funder

Cancerfonden

Barncancerfonden

Publisher

Wiley

Reference20 articles.

1. Ueber asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung

2. Context is everything: aneuploidy in cancer

3. MitelmanF JohanssonB MertensF.Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.https://mitelmandatabase.isb-cgc.org

4. Aneuploidy in Cancer and Aging

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