Context is everything: aneuploidy in cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
https://www.nature.com/articles/s41576-019-0171-x.pdf
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3. van Jaarsveld, R. H. & Kops, G. Difference makers: chromosomal instability versus aneuploidy in cancer. Trends Cancer 2, 561–571 (2016).
4. Sheltzer, J. M. & Amon, A. The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends Genet. 27, 446–453 (2011).
5. Sheltzer, J. M. et al. Single-chromosome gains commonly function as tumor suppressors. Cancer Cell 31, 240–255 (2017). This study shows that the experimental introduction of extra chromosomes into mammalian cells is tumour-suppressive.
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