Severe Acute Malnutrition Results in Lower Lumefantrine Exposure in Children Treated With Artemether‐Lumefantrine for Uncomplicated Malaria

Author:

Chotsiri Palang1,Denoeud‐Ndam Lise2,Baudin Elisabeth2ORCID,Guindo Ousmane3,Diawara Halimatou4,Attaher Oumar4,Smit Michiel5,Guerin Philippe J.67,Doumbo Ogobara K.8,Wiesner Lubbe5,Barnes Karen I.56ORCID,Hoglund Richard M.17,Dicko Alassane8,Etard Jean‐Francois29,Tarning Joel167ORCID

Affiliation:

1. Mahidol‐Oxford Tropical Medicine Research UnitFaculty of Tropical MedicineMahidol University Bangkok Thailand

2. Epicentre Paris France

3. Epicentre Maradi Niger

4. Malaria Research and Training CentreFaculty of Medicine Pharmacy and DentistryUniversity of Bamako Bamako Mali

5. Division of Clinical PharmacologyDepartment of MedicineUniversity of Cape Town Cape Town South Africa

6. WorldWide Antimalarial Resistance Network (WWARN) Oxford UK

7. Centre for Tropical Medicine and Global HealthNuffield Department of MedicineOxford University Oxford UK

8. Malaria Research and Training CenterFaculté de Médecine et d'Odonto‐stomatologie et Faculté de PharmacieUniversité des Sciences Techniques et Technologies de Bamako Bamako Mali

9. TransVIHMI UMI 233Institut de recherche pour le développement (IRD)Inserm U 1175Montpellier 1 University Montpellier France

Funder

Bill and Melinda Gates Foundation

Wellcome Trust

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference41 articles.

1. World Health Organization (WHO) 2018 World Health Organization Geneva Switzerland

2. Malnutrition as an underlying cause of childhood deaths associated with infectious diseases in developing countries;Rice A.L.;Bull. World Health Organ.,2000

3. World Health Organization (WHO) & United Nations Children's Fund.WHO Child Growth Standards and the Identification of Severe Acute Malnutrition in Infants and Children(World Health Organization Geneva Switzerland 2009).

4. Quinine disposition in globally malnourished children with cerebral malaria

5. Drug Metabolism and Pharmacokinetics in Malnutrition

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