Cross‐disciplinary mathematical modelling to benefit healthcare – could clinical pharmacology play an enabling role?

Author:

Maluleke Tirhani12ORCID,Benecke Rohan3,Oladejo Sunday4,Feulner Georg5,Kern Steve6,Lister Johanna7,McClelland Gabriel8,Njoki Miriam9,Noack Patrick10,Petruccione Francesco411,Rajaratnam Kanshukan4,Waitt Catriona1213,Rosenkranz Bernd2314,Pillai Goonaseela151617ORCID

Affiliation:

1. F. Hoffmann La‐Roche Johannesburg South Africa

2. Fundisa African Academy of Medicines Development Cape Town South Africa

3. Division of Clinical Pharmacology, Faculty of Medicine and Health Sciences Stellenbosch University Cape Town South Africa

4. School for Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa

5. Potsdam Institute for Climate Impact Research, Member of the Leibniz Association Potsdam Germany

6. Global Health Labs, Bellevue Bellevue Washington USA

7. Takeda Pharmaceuticals Zürich Switzerland

8. McClelland Creative EF Feuerthalen Switzerland

9. Science For Africa (SFA) Foundation Nairobi Kenya

10. University of Applied Sciences Weihenstephan‐Triesdorf Germany

11. National Institute for Theoretical and Computational Sciences (NITheCS) Stellenbosch South Africa

12. Department of Pharmacology and Therapeutics University of Liverpool Liverpool UK

13. Infectious Diseases Institute Makerere University College of Health Sciences Kampala Uganda

14. Institute for Clinical Pharmacology and Toxicology Charité Universitätsmedizin Berlin Germany

15. CP+ Associates GmbH Basel Switzerland

16. Division of Clinical Pharmacology University of Cape Town Cape Town South Africa

17. Pharmacometrics Africa NPC Cape Town South Africa

Abstract

AbstractClinical pharmacology is often the nexus in any cross‐disciplinary team that is seeking solutions for human healthcare issues. The use and application of real‐world data and artificial intelligence to better understand our ecosystem has influenced our view at the world and how we do things. This has resulted in remarkable advancements in the healthcare space and development of personalized medicines with great attributes from the application of models and simulations, contributing to a more efficient healthcare development process. A cross‐disciplinary symposium was held in December 2023, whereby experts from different scientific disciplines engaged in a high‐level discussion on the opportunities and challenges of mathematical models in different fields, possible future developments and decision making. A strong interlink amongst the disciplines represented was apparent, with clinical pharmacology identified as the one which integrates various scientific disciplines. Deliberate and strategic cross‐disciplinary dialogues are required to break out of the silos and implement integration for efficiency and cost‐effectiveness of novel interventions.

Publisher

Wiley

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