Comprehensive dosimetric characterization of novel silicon carbide detectors with UHDR electron beams for FLASH radiotherapy

Author:

Milluzzo Giuliana1,De Napoli Marzio1,Di Martino Fabio234,Amato Antonino56,Del Sarto Damiano23,D'Oca Maria Cristina17,Marrale Maurizio16,Masturzo Luigi238,Medina Elisabetta910,Okpuwe Chinonso11112,Pensavalle Jake Harold238,Vignati Anna910,Camarda Massimo513,Romano Francesco114

Affiliation:

1. National Institute of Nuclear Physics (INFN) Catania Division Catania Italy

2. Centro Pisano ricerca e implementazione clinica Flash Radiotherapy (CPFR@CISUP) Pisa Italy

3. Fisica Sanitaria Azienda Ospedaliero Universitaria Pisa AOUP Pisa Italy

4. National Institute of Nuclear Physics (INFN) Pisa Division Pisa Italy

5. STLab srl Catania Italy

6. National Institute of Nuclear Physics (INFN) Laboratori Nazionali del Sud Catania Italy

7. Department of Physics and Chemistry “Emilio Segrè” University of Palermo Palermo Italy

8. SIT‐Sordina Aprilia Italy

9. Physics Department University of Torino Torino Italy

10. National Institute of Nuclear Physics (INFN) Torino Division Torino Italy

11. Physics Department University of Catania Catania Italy

12. Department of Physics Federal University of Technology Owerri Owerri Nigeria

13. SenSiC GmbH Villigen Switzerland

14. Particle Therapy Research Center (PARTREC) Department of Radiation Oncology University Medical Center Groningen, University of Groningen Groningen The Netherlands

Abstract

AbstractBackground: The extremely fast delivery of doses with ultra high dose rate (UHDR) beams necessitates the investigation of novel approaches for real‐time dosimetry and beam monitoring. This aspect is fundamental in the perspective of the clinical application of FLASH radiotherapy (FLASH‐RT), as conventional dosimeters tend to saturate at such extreme dose rates.Purpose: This study aims to experimentally characterize newly developed silicon carbide (SiC) detectors of various active volumes at UHDRs and systematically assesses their response to establish their suitability for dosimetry in FLASH‐RT.Methods: SiC PiN junction detectors, recently realized and provided by STLab company, with different active areas (ranging from 4.5 to 10 mm2) and thicknesses (10–20 µm), were irradiated using 9 MeV UHDR pulsed electron beams accelerated by the ElectronFLASH linac at the Centro Pisano for FLASH Radiotherapy (CPFR). The linearity of the SiC response as a function of the delivered dose per pulse (DPP), which in turn corresponds to a specific instantaneous dose rate, was studied under various experimental conditions by measuring the produced charge within the SiC active layer with an electrometer. Due to the extremely high peak currents, an external customized electronic RC circuit was built and used in conjunction with the electrometer to avoid saturation.Results: The study revealed a linear response for the different SiC detectors employed up to 21 Gy/pulse for SiC detectors with 4.5 mm2/10 µm active area and thickness. These values correspond to a maximum instantaneous dose rate of 5.5 MGy/s and are indicative of the maximum achievable monitored DPP and instantaneous dose rate of the linac used during the measurements.Conclusions: The results clearly demonstrate that the developed devices exhibit a dose‐rate independent response even under extreme instantaneous dose rates and dose per pulse values. A systematic study of the SiC response was also performed as a function of the applied voltage bias, demonstrating the reliability of these dosimeters with UHDR also without any applied voltage. This demonstrates the great potential of SiC detectors for accurate dosimetry in the context of FLASH‐RT.

Funder

Fondazione Pisa

Publisher

Wiley

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