Prediction of human drug clearance from animal data: Application of the rule of exponents and ‘fu corrected intercept method’ (FCIM)
Author:
Publisher
Elsevier BV
Subject
Pharmaceutical Science
Reference19 articles.
1. First-time-in-human dose selection: Allometric thoughts and perspectives;Boxenbaum;J Clin Pharmacol,1995
2. First-in-human dose selection;Mahmood,2005
3. Estimating the starting dose for entry into humans: Principles and practice;Reigner;Eur J Clin Pharmacol,2002
4. Interspecies scaling of clearance;Mahmood,2005
5. Scaling of antipyrine intrinsic clearance of unbound drug on 15 mammalian species;Boxenbaum;Eur J Drug Metab Pharmacokinet,1984
Cited by 31 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Methodical advances in reproducibility research: A proof of concept qualitative comparative analysis of reproducing animal data in humans;Journal of Neuroscience Methods;2023-09
2. Practical Application of Pk/TK Models: Preclinical PK/TK and Clinical Trial;Handbook of Pharmacokinetics and Toxicokinetics;2023-07-03
3. Predicting animal to human translation: A proof of concept study using qualitative comparative analysis;2022-02-01
4. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data;Drug Metabolism and Pharmacokinetics;2020-08
5. Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver;Xenobiotica;2019-09-13
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3