Affiliation:
1. Department of Microbiology and Immunology School of Basic Medical Sciences Shanxi Medical University Taiyuan Shanxi 030001 China
2. Laboratory of Morphology Shanxi Medical University Taiyuan Shanxi 030001 China
3. Department of Endocrinology Affiliated Hospital of Yunnan University Kunming Yunnan 650021 China
Abstract
ScopeObesity has been recognized as a worldwide public health crisis, this is accompanied by dysregulation of the intestinal microbiota and upregulation of liver steatosis and adipose inflammation. Synbiotic as a novel alternative therapy for obesity have recently gained much attention.MethodsThis study innovatively research the anti‐obesity properties of a newly synbiotic composed of Lactobacillus acidophilus, Bifidobacterium infantis and konjac glucomannan oligosaccharides.ResultsThe synbiotic treatment can reduce body weight, fat mass, blood sugar, liver steatosis and adipose inflammation in obesity mice fed by high‐fat diet (HFD). Meanwhile, synbiotic treatment activated brown adipose tissue and improve energy, glucose and lipid metabolism. In addition, synbiotic treatment not solely enhanced the protection of intestinal barrier, but also ameliorated gut microbiota dysbiosis directly by enhancing beneficial microbes and reducing potentially harmful bacteria. Furthermore, the microbiome phenotype and functional prediction showed that synbiotic treatment can improve the gut microbiota functions involving inflammatory state, immune response, metabolism and pathopoiesia.ConclusionThe synbiotic may be an effective candidate treatment strategy for the clinical prevention and treatment of obesity and other associated metabolic diseases such as hyperlipidemia, nonalcoholic fatty liver diseases by alleviating inflammatory response, regulating energy metabolism and maintaining the balance of intestinal microecology.
Funder
Shanxi Scholarship Council of China
Natural Science Foundation of Shanxi Province
Shanxi Province Science Foundation for Youths
Subject
Food Science,Biotechnology
Cited by
6 articles.
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