Is an infectious trigger always required for primary hemophagocytic lymphohistiocytosis? Lessons from in utero and neonatal disease

Author:

Heeg Maximilian123ORCID,Ammann Sandra14,Klemann Christian12,Panning Marcus5,Falcone Valeria5,Hengel Harmut5,Lehmberg Kai67,zur Stadt Udo67,Wustrau Katharina67,Janka Gritta6,Ehl Stephan12

Affiliation:

1. Center for Chronic Immunodeficiency; Medical Center University of Freiburg, Faculty of Medicine; Freiburg Germany

2. Center for Pediatrics; Medical Center, University of Freiburg, Faculty of Medicine; Freiburg Germany

3. Berta-Ottenstein-Programme, Faculty of Medicine; University of Freiburg; Freiburg Germany

4. Cambridge Institute for Medical Research; Biomedical Campus; Cambridge United Kingdom

5. Institute of Virology, University Medical Center; Faculty of Medicine; Albert-Ludwigs-University of Freiburg; Freiburg Germany

6. Department of Pediatric Hematology and Oncology; University Medical Center Hamburg-Eppendorf; Hamburg Germany

7. Divison of Pediatric Stem Cell Transplantation and Immuology; University Medical Center Hamburg-Eppendorf; Hamburg Germany

Funder

Deutsche Kinderkrebsstiftung

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Reference13 articles.

1. Hemophagocytic syndrome: primary forms and predisposing conditions;Sepulveda;Curr Opin Immunol,2017

2. Familial hemophagocytic lymphohistiocytosis: how late can the onset be?;Allen;Haematologica,2001

3. Debate around infection-dependent hemophagocytic syndrome in paediatrics;Ansuini;BMC Infect Dis,2013

4. the role of infections in primary hemophagocytic lymphohistiocytosis: a case series and review of the literature;Sung;Clin Infect Dis,2001

5. Familial hemophagocytic lymphohistiocytosis and viral infections;Henter;Acta Paediatr,1993

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