Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV-Reference-Cited by-同舟云学术

Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV

Published:2023-08-12 Issue:4 Volume:94 Page:798-802
ISSN:0364-5134
Container-title:Annals of Neurology
language:en
Short-container-title:Annals of Neurology

Author:

Angelovich Thomas A.¹²³^ORCID,Cochrane Catherine R.¹⁴^ORCID,Zhou Jingling¹,Tumpach Carolin³,Byrnes Sarah J.¹^ORCID,Jamal Eddine Janna¹^ORCID,Waring Emily¹,Busman‐Sahay Kathleen⁵^ORCID,Deleage Claire⁶,Jenkins Trisha A.¹^ORCID,Hearps Anna C.²⁷^ORCID,Turville Stuart⁸^ORCID,Gorry Paul R.¹^ORCID,Lewin Sharon R.³⁹¹⁰^ORCID,Brew Bruce J.¹¹¹²^ORCID,Estes Jacob D.¹⁵^ORCID,Roche Michael¹³^ORCID,Churchill Melissa J.¹²¹³^ORCID

Affiliation:

1. Infectious and Inflammatory Diseases, School of Health and Biomedical Sciences RMIT University Melbourne Victoria Australia

2. Life Sciences Discipline Burnet Institute Melbourne Victoria Australia

3. Department of Infectious Diseases The University of Melbourne at the Peter Doherty Institute for Infection and Immunity Melbourne Victoria Australia

4. Department of Medicine, The Royal Melbourne Hospital The University of Melbourne Melbourne Victoria Australia

5. Vaccine and Gene Therapy Institute, Oregon Health & Science University Hillsboro Oregon USA

6. AIDS and Cancer Virus Program Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research Frederick Maryland USA

7. Central Clinical School Monash University Melbourne Victoria Australia

8. The Kirby Institute, University of New South Wales Kensington New South Wales Australia

9. Department of Infectious Diseases Alfred Hospital and Monash University Melbourne Victoria Australia

10. Victorian Infectious Diseases Service Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity Melbourne Victoria Australia

11. Peter Duncan Neurosciences Unit, Departments of Neurology and Immunology St. Vincent's Hospital University of New South Wales Sydney New South Wales Australia

12. University of Notre Dame Sydney New South Wales Australia

13. Departments of Microbiology and Medicine Monash University Melbourne Victoria Australia

Abstract

Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and cerebellum relative to frontal white matter. Intact proviruses were primarily found in the frontal white matter but also detected in other brain regions of PWH, demonstrating frontal white matter as a major brain reservoir of intact, potentially replication competent HIV DNA that persists despite antiretroviral therapy. ANN NEUROL 2023;94:798–802

Funder

National Health and Medical Research Council

National Institute on Drug Abuse

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.26750

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