Design, and synthesis of <i>N</i> ‐benzyl spiro‐piperidine hydroxamic acid‐based derivatives: Histone deacetylase inhibitory activity and drug‐likeness prediction-Reference-Cited by-同舟云学术

Design, and synthesis of N ‐benzyl spiro‐piperidine hydroxamic acid‐based derivatives: Histone deacetylase inhibitory activity and drug‐likeness prediction

Published:2022-07-27 Issue:11 Volume:59 Page:2006-2015
ISSN:0022-152X
Container-title:Journal of Heterocyclic Chemistry
language:en
Short-container-title:Journal of Heterocyclic Chem

Author:

Kurapati Chidvilas¹,Paidikondala Kalyani²,Badavath Vishnu Nayak³^ORCID,Parveen Sabnam⁴,Singh Om V.¹,Gundla Rambabu¹^ORCID

Affiliation:

1. Department of Chemistry, School of Science GITAM Deemed to be University Hyderabad Telangana India

2. Department of Chemistry KG Reddy College of Engineering & Technology Hyderabad Telangana India

3. Department of Pharm. Chemistry, School of Pharmacy & Technology Management SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Hyderabad Telangana India

4. Department of Pharm. Chemistry, Chitkara College Pharmacy Chitkara University Rajpura Punjab India

Funder

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

Wiley

Subject

Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jhet.4538

Reference20 articles.

1. Histone deacetylase (HDAC) inhibitors in cancer: a patent review (2017-present)

2. A Review of Progress in Histone Deacetylase 6 Inhibitors Research: Structural Specificity and Functional Diversity

3. Discovery, Synthesis, and Pharmacological Evaluation of Spiropiperidine Hydroxamic Acid Based Derivatives as Structurally Novel Histone Deacetylase (HDAC) Inhibitors

4. Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity

5. Synthesis and antitumor activity evaluation of chrysin derivatives

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