Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance

Author:

Martin Claire A.1,Cullinane Carleen12,Kirby Laura1,Abuhammad Shatha12,Lelliott Emily J.12,Waldeck Kelly1,Young Richard J.1,Brajanovski Natalie1,Cameron Donald P.1,Walker Rachael1,Sanij Elaine13,Poortinga Gretchen124,Hannan Ross D.12567,Pearson Richard B.1256,Hicks Rodney J.12,McArthur Grant A.124,Sheppard Karen E.125ORCID

Affiliation:

1. Cancer Research DivisionPeter MacCallum Cancer CentreEast MelbourneVicAustralia

2. Sir Peter MacCallum Department of OncologyUniversity of MelbourneParkville Vic Australia

3. Department of PathologyUniversity of MelbourneParkville Vic Australia

4. Department of MedicineSt. Vincent's Hospital, University of MelbourneParkville Vic Australia

5. Department of Biochemistry and Molecular BiologyUniversity of MelbourneParkville Vic Australia

6. Department of Biochemistry and Molecular BiologyMonash UniversityClayton Vic Australia

7. School of Biomedical SciencesUniversity of QueenslandBrisbane Qld Australia

Funder

National Health and Medical Research Council

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference53 articles.

1. Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

2. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

3. Five‐year overall survival (OS) update from a phase II, open‐label trial of dabrafenib (D) and trametinib (T) in patients (pts) with BRAF V600‐mutant unresectable or metastatic melanoma (MM);Long GV;J Clin Oncol,2017

4. Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

5. BRAF Inhibitor Resistance Mechanisms in Metastatic Melanoma: Spectrum and Clinical Impact

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