Author:
Chen Wanxian,Geng Deyi,Chen Jiasheng,Han Xiaosha,Xie Qihu,Guo Genghong,Chen Xuefen,Zhang Wancong,Tang Shijie,Zhong Xiaoping
Abstract
Abstract
Background
Despite advances in therapeutic strategies, resistance to immunotherapy and the off-target effects of targeted therapy have significantly weakened the benefits for patients with melanoma.
Main body
Alternative splicing plays a crucial role in transcriptional reprogramming during melanoma development. In particular, aberrant alternative splicing is involved in the efficacy of immunotherapy, targeted therapy, and melanoma metastasis. Abnormal expression of splicing factors and variants may serve as biomarkers or therapeutic targets for the diagnosis and prognosis of melanoma. Therefore, comprehensively integrating their roles and related mechanisms is essential. This review provides the first detailed summary of the splicing process in melanoma and the changes occurring in this pathway.
Conclusion
The focus of this review is to provide strategies for developing novel diagnostic biomarkers and summarize their potential to alter resistance to targeted therapies and immunotherapy.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangdong Province
Shantou Science and Technology Project
Publisher
Springer Science and Business Media LLC
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