CD33 ‐directed immunotherapy with third‐generation chimeric antigen receptor T cells and gemtuzumab ozogamicin in intact and CD33 ‐edited acute myeloid leukemia and hematopoietic stem and progenitor cells

Author:

Liu Yi12ORCID,Wang Sanmei13,Schubert Maria‐Luisa1,Lauk Annika1,Yao Hao1,Blank Maximilian Felix1,Cui Chunhong14,Janssen Maike1,Schmidt Christina1,Göllner Stefanie1,Kleist Christian5,Zhou Fengbiao1,Rahfeld Jens‐Ulrich6,Sauer Tim1,Schmitt Michael1ORCID,Müller‐Tidow Carsten12

Affiliation:

1. Department of Medicine V Heidelberg University Hospital Heidelberg Germany

2. Molecular Medicine Partnership Unit (MMPU) European Molecular Biology Laboratory (EMBL) and Heidelberg University Hospital Heidelberg Germany

3. Department of Hematology First Affiliated Hospital of Nanjing Medical University, Collaborative Innovation Center for Cancer Personalized Medicine Nanjing China

4. Shanghai University of Medicine and Health Sciences Shanghai China

5. Department of Nuclear Medicine Heidelberg University Hospital Heidelberg Germany

6. Fraunhofer Institute for Cell Therapy and Immunology IZI Halle Germany

Funder

Deutsche Forschungsgemeinschaft

Deutsche Krebshilfe

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference59 articles.

1. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

2. Clonal selection with RAS pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in acute myeloid;McMahon CM;Leukemia,2019

3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207997s000lbl.pdf

4. https://www.ema.europa.eu/en/documents/product-information/rydapt-epar-product-information_en.pdf

5. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/211349s000lbl.pdf

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