Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker

Author:

Mollica Adriano1,Costante Roberto1,Stefanucci Azzurra2,Pinnen Francesco1,Lucente Gino3,Fidanza Stefano4,Pieretti Stefano5

Affiliation:

1. Dipartimento di Farmacia; Università di Chieti-Pescara “G. d'Annunzio”; Via dei Vestini 31 66100 Chieti Italy

2. Dipartimento di Chimica, Facoltà di S.M.F.N.; “Sapienza” Università di Roma; P.le A. Moro 5 00185 Rome Italy

3. Istituto di Chimica Biomolecolare (CNR) c/o Dipartimento di Chimica e Tecnologie del Farmaco, “Sapienza”; Università di Roma; P.le A.Moro 00185 Rome Italy

4. Dipartimento di Farmacologia; Istituto Superiore di Sanità; Viale Regina Elena 299 00161 Rome Italy

5. Dipartimento del Farmaco; Istituto Superiore di Sanità; Viale Regina Elena 299 00161 Rome Italy

Publisher

Wiley

Subject

Organic Chemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry,Structural Biology

Reference38 articles.

1. Double-enkephalins-synthesis, activity on guinea-pig ileum, and analgesic effect;Lipkowski;Peptides,1982

2. Receptor binding and biological activity of bivalent enkephalins;Costa;Biochem. Pharmacol.,1985

3. Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin;Lipkowski;Bioorg. Med. Chem. Lett.,1999

4. Antinociceptive profile of biphalin, a dimeric enkephalin analog;Horan;J. Pharmacol. Exp. Ther.,1993

5. Intrathecal antinociceptive interaction between the NMDA antagonist ketamine and the opioids, morphine and biphalin;Kosson;Eur. J. Pain,2008

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