Discovery of κ Opioid Receptor (KOR)-Selective d-Tetrapeptides with Improved In Vivo Antinociceptive Effect after Peripheral Administration

Author:

Stefanucci Azzurra1ORCID,Della Valle Alice1,Scioli Giuseppe1,Marinaccio Lorenza1,Pieretti Stefano2ORCID,Minosi Paola2,Szucs Edina3,Benyhe Sandor3,Masci Domiziana4,Tanguturi Parthasaradhireddy5,Chou Kerry5,Barlow Deborah6,Houseknecht Karen6,Streicher John M.5,Mollica Adriano1ORCID

Affiliation:

1. Dipartimento di Farmacia, Università di Chieti-Pescara “G. d’Annunzio”, Via dei Vestini 31, 66100 Chieti, Italy

2. Istituto Superiore di Sanità, Centro Nazionale Ricerca e Valutazione Preclinica e Clinica dei farmaci, Viale Regina Elena 299, 00161 Rome, Italy

3. Institute of Biochemistry, Biological Research Centre, 6726 Szeged, Hungary

4. Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy

5. Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, United States

6. Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, Maine 04005, United States

Funder

Ministero dell?Istruzione, dell?Universit? e della Ricerca

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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