Assessment of the performance of the TGx‐DDI biomarker to detect DNA damage‐inducing agents using quantitative RT‐PCR in TK6 cells-Reference-Cited by-同舟云学术

Assessment of the performance of the TGx‐DDI biomarker to detect DNA damage‐inducing agents using quantitative RT‐PCR in TK6 cells

Published:2018-11-29 Issue:2 Volume:60 Page:122-133
ISSN:0893-6692
Container-title:Environmental and Molecular Mutagenesis
language:en
Short-container-title:Environ Mol Mutagen

Author:

Cho Eunnara¹²,Buick Julie K.¹,Williams Andrew¹,Chen Renxiang³,Li Heng‐Hong³⁴,Corton J. Christopher⁵^ORCID,Fornace Albert J.³⁴,Aubrecht Jiri⁶,Yauk Carole L.¹²

Affiliation:

1. Environmental Health Science and Research BureauHealth Canada Ottawa Ontario Canada

2. Department of BiologyCarleton University Ottawa Ontario Canada

3. Department of Oncology, Lombardi Comprehensive Cancer CenterGeorgetown University Medical Center Washington District of Columbia

4. Department of Biochemistry and Molecular and Cellular BiologyGeorgetown University Medical Center Washington District of Columbia

5. Integrated Systems Toxicology DivisionNHEERL, US‐EPA Durham North Carolina

6. Takeda Pharmaceuticals USA Inc. Cambridge Massachusetts

Funder

Health Canada

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Genetics(clinical),Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/em.22257

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4. Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK 6 cells

5. Integration of the TGx-28.65 genomic biomarker with the flow cytometry micronucleus test to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human TK6 cells

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