Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK 6 cells-Reference-Cited by-同舟云学术

Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK 6 cells

Published:2015-03-02 Issue:6 Volume:56 Page:520-534
ISSN:0893-6692
Container-title:Environmental and Molecular Mutagenesis
language:en
Short-container-title:Environ. Mol. Mutagen.

Author:

Buick Julie K.¹,Moffat Ivy¹²,Williams Andrew¹,Swartz Carol D.³,Recio Leslie³,Hyduke Daniel R.⁴⁵⁶,Li Heng‐Hong⁵⁶,Fornace Albert J.⁵⁶,Aubrecht Jiri⁷,Yauk Carole L.¹

Affiliation:

1. Environmental Health Science and Research Bureau, Health CanadaOttawa Ontario Canada

2. Water and Air Quality Bureau, Health CanadaOttawa Ontario Canada

3. Integrated Laboratory Systems Inc.Research Triangle Park North Carolina

4. Biological Engineering DepartmentUtah State UniversityLogan Utah

5. Department of Biochemistry and Molecular and Cellular BiologyGeorgetown University Medical CenterWashington District of Columbia

6. Department of OncologyGeorgetown University Medical CenterWashington District of Columbia

7. Drug Safety Research and Development, Pfizer Inc.Groton Connecticut

Funder

Health Canada

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Genetics (clinical),Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/em.21940

Reference27 articles.

1. Stress-specific signatures: expression profiling of p53 wild-type and -null human cells

2. Genomic Profiling Uncovers a Molecular Pattern for Toxicological Characterization of Mutagens and Promutagens In Vitro

3. Minimum information about a microarray experiment (MIAME)—toward standards for microarray data

4. Differentiation of DNA reactive and non-reactive genotoxic mechanisms using gene expression profile analysis

5. Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

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