A magic bullet to specifically eliminate mutated mitochondrial genomes from patients' cells
Author:
Affiliation:
1. Neurology and Cell Biology University of Miami Miller School of Medicine Miami FL USA
Publisher
EMBO
Subject
Molecular Medicine
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/emmm.201303769
Reference9 articles.
1. Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease
2. Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease
3. Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs
4. The implications of mitochondrial DNA copy number regulation during embryogenesis
5. Mitochondrially targeted ZFN s for selective degradation of pathogenic mitochondrial genomes bearing large‐scale deletions or point mutations
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