Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data

Author:

Tylee Daniel S.1ORCID,Sun Jiayin1,Hess Jonathan L.1,Tahir Muhammad A.1,Sharma Esha1,Malik Rainer2,Worrall Bradford B.3ORCID,Levine Andrew J.4,Martinson Jeremy J.5,Nejentsev Sergey6,Speed Doug7,Fischer Annegret8,Mick Eric9,Walker Brian R.10,Crawford Andrew1011,Grant Struan F. A.12131415,Polychronakos Constantin16,Bradfield Jonathan P.1217,Sleiman Patrick M. A.1214,Hakonarson Hakon1214,Ellinghaus Eva8,Elder James T.18,Tsoi Lam C.1819,Trembath Richard C.20,Barker Jonathan N.20,Franke Andre8,Dehghan Abbas21,Faraone Stephen V.122,Glatt Stephen J.1, , , , , ,

Affiliation:

1. Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), Departments of Psychiatry and Behavioral Sciences & Neuroscience and Physiology; SUNY Upstate Medical University; Syracuse New York

2. Institute for Stroke and Dementia Research; Klinikum der Universität München, Ludwig-Maximilians-University (LMU); Munich Germany

3. Departments of Neurology and Public Health Sciences; University of Virginia School of Medicine; Charlottesville Virginia

4. Department of Neurology, David Geffen School of Medicine; University of California Los Angeles; Los Angeles California

5. Department of Infectious Diseases and Microbiology; Graduate School of Public Health, University of Pittsburgh; Pennsylvania

6. Department of Medicine; University of Cambridge; Cambridge United Kingdom

7. Genetics Institute; University College London; WC1E 6BT, London United Kingdom

8. Institute of Clinical Molecular Biology; Christian Albrechts University of Kiel; Kiel Germany

9. Department of Quantitative Health Sciences; University of Massachusetts Medical School; Worcester Massachusetts

10. BHF Centre for Cardiovascular Science, Queen's Medical Research Institute; University of Edinburgh; Edinburgh EH16 4TJ United Kingdom

11. School of Social and Community Medicine, MRC Integrated Epidemiology Unit; University of Bristol; Bristol BS8 2BN United Kingdom

12. Center for Applied Genomics, Division of Human Genetics; The Children's Hospital of Philadelphia; Philadelphia Pennsylvania

13. Division of Endocrinology and Diabetes; The Children's Hospital of Philadelphia; Philadelphia Pennsylvania

14. Department of Pediatrics, Perelman School of Medicine; University of Pennsylvania; Philadelphia Pennsylvania

15. Institute of Diabetes, Obesity and Metabolism; Perelman School of Medicine, University of Pennsylvania; Philadelphia Pennsylvania

16. Endocrine Genetics Laboratory, Department of Pediatrics and the Child Health Program of the Research Institute; McGill University Health Centre; Montreal Quebec Canada

17. Quantinuum Research LLC; San Diego California

18. Department of Dermatology, Veterans Affairs Hospital; University of Michigan; Ann Arbor Michigan

19. Department of Biostatistics; University of Michigan; Ann Arbor Michigan

20. Division of Genetics and Molecular Medicine; King's College London; London UK

21. Department of Biostatistics and Epidemiology; MRC-PHE Centre for Environment and Health School of Public Health, Imperial College London; London United Kingdom

22. K.G. Jebsen Centre for Research on Neuropsychiatric Disorders; University of Bergen; Bergen Norway

Funder

Autism Speaks

Brain and Behavior Research Foundation

Gerber Foundation

National Alliance for Research on Schizophrenia and Depression

National Institutes of Health

NIHR Cambridge Biomedical Research Centre

Sidney R. Baer, Jr. Foundation

UCLA Center for AIDS Research

Vascular Dementia Research Foundation

Wellcome Trust

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Psychiatry and Mental health,Genetics (clinical)

Reference129 articles.

1. Otitis media in children with learning disabilities and in children with attention deficit disorder with hyperactivity;Adesman;Pediatrics,1990

2. Genome-wide association study identifies 27 loci influencing concentrations of circulating cytokines and growth factors;Ahola-Olli;American Journal of Human Genetics,2017

3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47;Anderson;Nature Genetics,2011

4. A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity;Andrade;Scientific Reports,2016

5. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia;Anney;Molecular Autism,2017

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