Epithelial growth factor receptor tyrosine kinase inhibitors alleviate house dust mite allergen Der p 2-induced IL-6 and IL-8

Author:

Pan Hui-Hsien123,Hsiao Yu-Ping134,Chen Ping-Ju1,Kang Yu-Ting1,Chao Yu-Hua35,Sheu Ji-Nan35,Lue Ko-Huang123,Ko Jiunn-Liang126ORCID

Affiliation:

1. Institute of Medicine; Chung Shan Medical University; Taichung Taiwan

2. Department of Pediatrics, Chung Shan Medical University Hospital; Institute of Allergy, Immunology, and Rheumatology; Taichung Taiwan

3. School of Medicine; Chung Shan Medical University; Taichung Taiwan

4. Department of Dermatology; Chung Shan Medical University Hospital; Taichung Taiwan

5. Department of Pediatrics; Chung Shan Medical University Hospital; Taichung Taiwan

6. Department of Medical Oncology and Chest Medicine; Chung Shan Medical University Hospital; Taichung Taiwan

Funder

Chung-Shan Medical University Hospital

Ministry of Science and Technology, Taiwan

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Management, Monitoring, Policy and Law,Toxicology,General Medicine

Reference44 articles.

1. Comorbidities and elevated IL-6 associate with negative outcome in adult-onset asthma;Ilmarinen;Eur Respir J,2016

2. Significant increase of IL-8 sputum levels in treatment resistant severe asthma compared with difficult to treat severe asthma patients;Ernst;J Genet Syndr Gene Ther,2014

3. House dust mite and cockroach exposure are strong risk factors for positive allergy skin test responses in the childhood asthma management program;Huss;J Allergy Clin Immunol,2001

4. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium;King;J Immunol,1998

5. Induction of IL-6 and IL-8 by house dust mite allergen Der p1 in cultured human nasal epithelial cells is associated with PAR/PI3K/NFkappaB signaling;Shi;ORL J Otorhinolaryngol Relat Spec,2010

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