Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer

Author:

Hassanein Mohamed1,Qian Jun1,Hoeksema Megan D.1,Wang Jing2,Jacobovitz Marie1,Ji Xiangming1,Harris Fredrick T.13,Harris Bradford K.1,Boyd Kelli L.4,Chen Heidi5,Eisenberg Rosana4,Massion Pierre P.16

Affiliation:

1. Thoracic Program, Vanderbilt-Ingram Comprehensive Cancer Center and Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University; Nashville TN

2. Department of Biomedical Informatics; Vanderbilt University; Nashville TN

3. Department of Biochemistry and Cancer Biology; Meharry Medical College; Nashville TN

4. Department of Pathology; Microbiology and Immunology, Vanderbilt University; Nashville TN

5. Department of Biostatistics; Vanderbilt University; Nashville TN

6. Veterans Affairs, Tennessee Valley Healthcare System; Nashville TN

Funder

Lung Cancer Research Foundation (LCRF), National Cancer Institute

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference31 articles.

1. Cancer treatment and survivorship statistics, 2012;Siegel;CA Cancer J Clin,2012

2. Amino acid metabolism in tumour-bearing mice;Rivera;Biochem J,1988

3. Cell cycle phase perturbations by 6-diazo-5-oxo-L-norleucine and acivicin in normal and neoplastic human cell lines;Huber;Br J Cancer,1987

4. Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium;Brower;Cancer Res,1986

5. Reductive glutamine metabolism by idh1 mediates lipogenesis under hypoxia;Metallo;Nature,2012

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