MurineCyp3aknockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans-Reference-Cited by-同舟云学术

MurineCyp3aknockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans

Published:2016-01 Issue:1 Volume:37 Page:3-14
ISSN:0142-2782
Container-title:Biopharmaceutics & Drug Disposition
language:en
Short-container-title:Biopharm. Drug Dispos.

Author:

Nakada Naoyuki¹,Kawamura Akio¹,Kamimura Hidetaka²,Sato Koya¹,Kazuki Yasuhiro³,Kakuni Masakazu⁴,Ohbuchi Masato¹,Kato Kota¹,Tateno Chise⁴⁵,Oshimura Mitsuo³,Usui Takashi¹

Affiliation:

1. Drug Metabolism Research Laboratories, Drug Discovery Research; Astellas Pharma Inc.; Osaka Japan

2. ADME & Tox Research Institute; Sekisui Medical Co., Ltd; Tokyo Japan

3. Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science; Tottori University; Yonago Tottori Japan

4. PhoenixBio, Co., Ltd; Higashi Hiroshima Hiroshima Japan

5. Liver Research Project Center; Hiroshima University; Japan

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference37 articles.

1. Why do metabolites circulate?;Smith;Xenobiotica,2012

2. Reactions and enzymes in the metabolism of drugs and other xenobiotics;Testa;Drug Discov Today,2012

3. FDA Guidance for Industry: Safety Testing of Drug Metabolites Rockville, MD, USA 2008

4. ICH ICH Guideline M3 (R2): Guidance on Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals Geneva, Switzerland 2009

5. Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites;Dalvie;Chem Res Toxicol,2009

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