Computational design of a specific heavy chain/κ light chain interface for expressing fully IgG bispecific antibodies-Reference-Cited by-同舟云学术

Computational design of a specific heavy chain/κ light chain interface for expressing fully IgG bispecific antibodies

Published:2017-07-31 Issue:10 Volume:26 Page:2021-2038
ISSN:0961-8368
Container-title:Protein Science
language:en
Short-container-title:Protein Science

Author:

Froning K. J.¹,Leaver‐Fay A.²,Wu X.¹,Phan S.¹,Gao L.¹,Huang F.¹,Pustilnik A.¹,Bacica M.¹,Houlihan K.²,Chai Q.¹,Fitchett J. R.¹,Hendle J.¹,Kuhlman B.²³,Demarest S. J.¹

Affiliation:

1. Eli Lilly Biotechnology Center, 10300 Campus Point DriveSan Diego California92121

2. Department of Biochemistry and BiophysicsUniversity of North Carolina at Chapel HillChapel Hill North Carolina

3. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillChapel Hill North Carolina

Funder

U.S. Department of Energy

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pro.3240

Reference54 articles.

1. Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTβR

2. Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

3. Improving target cell specificity using a novel monovalent bispecific IgG design

4. Bispecific antibodies and CARs: generalized immunotherapeutics harnessing T cell redirection

5. Bispecific antibodies

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