Recent Advancements on Self‐Immolative System Based on Dynamic Covalent Bonds for Delivering Heterogeneous Payloads

Author:

Wang Qingbing12,Serda Maciej3,Li Quan45,Sun Tao2ORCID

Affiliation:

1. Department of Interventional Radiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Rui Jin Er Road Shanghai 200025 P. R. China

2. Key Laboratory of Smart Drug Delivery Ministry of Education Department of Pharmaceutics School of Pharmacy Fudan University 826 Zhangheng Road Shanghai 201203 P. R. China

3. Institute of Chemistry University of Silesia in Katowice Katowice 40‐006 Poland

4. School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine 10 Boyanghu Road Tianjin 301617 P. R. China

5. College of Chemistry and Chemical Engineering Hubei University 368 Youyidadao Avenue Wuhan 430062 P. R. China

Abstract

AbstractThe precisely spatial‐temporal delivery of heterogeneous payloads from a single system with the same pulse is in great demand in realizing versatile and synergistic functions. Very few molecular architectures can satisfy the strict requirements of dual‐release translated from single triggers, while the self‐immolative systems based on dynamic covalent bonds represent the “state‐of‐art” of ultimate solution strategy. Embedding heterogeneous payloads symmetrically onto the self‐immolative backbone with dynamic covalent bonds as the trigger, can respond to the quasi‐bio‐orthogonal hallmarks which are higher at the disease's microenvironment to simultaneously yield the heterogeneous payloads (drug A/drug B or drug/reporter). In this review, the modular design principles are concentrated to illustrate the rules in tailoring useful structures, then the rational applications are enumerated on the aspects of drug codelivery and visualized drug‐delivery. This review, hopefully, can give the general readers a comprehensive understanding of the self‐immolative systems based on dynamic covalent bonds for delivering heterogeneous payloads.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3