Affiliation:
1. Australian Institute for Bioengineering and Nanotechnology (AIBN) The University of Queensland St Lucia QLD 4072 Australia
2. Institute of Biomedical Health Technology and Engineering and Institute of Systems and Physical Biology Shenzhen Bay Laboratory Shenzhen 518107 P. R. China
Abstract
AbstractSonodynamic therapy (SDT) combines ultrasound and sonosensitizers to produce toxic reactive oxygen species (ROS) for cancer cell killing. Due to the high penetration depth of ultrasound (US), SDT breaks the depth penetration barrier of conventional photodynamic therapy for the treatment of deeply seated tumors. A key point to enhance the therapeutic efficiency of SDT is the development of novel sonosensitizers with promoted ability for ROS production. Herein, ultrathin Fe‐doped bismuth oxychloride nanosheets with rich oxygen vacancies and bovine serum albumin coating on surface are designed as piezoelectric sonosensitizers (BOC‐Fe NSs) for enhanced SDT. The oxygen vacancies of BOC‐Fe NSs provide electron trapping sites to promote the separation of e−‐h+ from the band structure, which facilitates the ROS production under the ultrasonic waves. The piezoelectric BOC‐Fe NSs create a built‐in field and the bending bands, further accelerating the ROS generation with US irradiation. Furthermore, BOC‐Fe NSs can induce ROS generation by a Fenton reaction catalyzed by Fe ion with endogenous H2O2 in tumor tissues for chemodynamic therapy. The as‐prepared BOC‐Fe NSs efficiently inhibited breast cancer cell growth in both in vitro and in vivo tests. The successfully development of BOC‐Fe NSs provides a new nano‐sonosensitiser option for enhanced SDT for cancer therapy.
Funder
National Health and Medical Research Council
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
3 articles.
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