Affiliation:
1. Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 P. R. China
2. Center on Nanoenergy Research, School of Physical Science and Technology Guangxi University Nanning 530004 P. R. China
3. School of Nanoscience and Technology University of Chinese Academy of Sciences Beijing 100049 P. R. China
Abstract
AbstractSonodynamic therapy (SDT) is regarded as a new‐rising strategy for cancer treatment with low invasiveness and high tissue penetration, but the scarcity of high‐efficiency sonosensitizers has seriously hindered its application. Herein, the iron‐doped and oxygen‐deficient bismuth tungstate nanosheets (BWO‐Fe NSs) with piezotronic effect are synthesized for enhanced SDT. Due to the existence of oxygen defects introduced through Fe doping, the bandgap of BWO‐Fe is significantly narrowed so that BWO‐Fe can be more easily activated by exogenous ultrasound (US). The oxygen defects acting as the electron traps inhibit the recombination of US‐induced electrons and holes. More importantly, the dynamically renewed piezoelectric potential facilitates the migration of electrons and holes to opposite side and causes energy band bending, which further promotes the production of reactive oxygen species. Furthermore, Fe doping endows BWO‐Fe with Fenton reactivity, which converts hydrogen peroxide (H2O2) in tumor microenvironment into hydroxyl radicals (•OH), thereby amplifying the cellular oxidative damage and enhancing SDT. Both in vitro and in vivo experiments illustrate their high cytotoxicity and tumor suppression rate against refractory breast cancer in mice. This work may provide an alternative strategy to develop oxygen‐deficient piezoelectric sonosensitizers for enhanced SDT via doping metal ions.
Funder
Chinese Academy of Sciences
Fundamental Research Funds for the Central Universities
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry
Cited by
13 articles.
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