New t -butyl based aspartate protecting groups preventing aspartimide formation in Fmoc SPPS

Author:

Behrendt Raymond1,Huber Simon1,Martí Roger2,White Peter3

Affiliation:

1. Merck & Cie; Im Laternenacker 5 8200 Schaffhausen Switzerland

2. School of Engineering and Architecture; Bd de Pérolles 80 1705 Fribourg Switzerland

3. Merck Chemicals Ltd.; Padge Road Beeston NG9 2JR UK

Publisher

Wiley

Subject

Organic Chemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry,Structural Biology

Reference38 articles.

1. Manufacturing peptides as active pharmaceutical ingredients;Zompra;Future Med. Chem.,2009

2. Advances in automatic, manual and microwave-assisted solid-phase peptide synthesis;Sabatino;Curr. Opin. Drug Discovery Dev.,2008

3. Some mechanistic aspects on Fmoc solid phase peptide synthesis;Pires;Int. J. Pept. Res. Ther.,2014

4. Fields GB Lauer-Fields JL Liu RQ Barany G 2nd edn Oxford Principles and practice of solid-phase peptide synthesis in Synth. PeptUniversity Press, Inc. New York 2002 93 219

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