A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses

Author:

Svensson Robin J.1,Aarnoutse Rob E.2,Diacon Andreas H.3,Dawson Rodney4,Gillespie Stephen H.5,Boeree Martin J.6,Simonsson Ulrika S.H.1

Affiliation:

1. Department of Pharmaceutical BiosciencesUppsala UniversityUppsala Sweden

2. Department of PharmacyRadboud University Medical CenterNijmegen the Netherlands

3. DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for TB ResearchDivision of Molecular Biology and Human Genetics, Stellenbosch University, Tygerberg, South Africa and TASK Applied SciencesCape Town South Africa

4. Department of Respiratory MedicineUniversity of Cape Town, Cape Town, South Africa and The Lung InstituteCape Town South Africa

5. School of MedicineUniversity of St. AndrewsSt. Andrews Fife UK

6. Department of Lung DiseasesRadboud University Medical Center, Nijmegen, the Netherlands and University Centre for Chronic Diseases DekkerswaldGroesbeek the Netherlands

Funder

Swedish Research Council

Bill and Melinda Gates Foundation

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

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