1. Graduate School of Pharmaceutical Sciences Osaka University 1-6, Yamada-oka, Suita Osaka 565-0871 Japan
2. Department of Formulation Design and Pharmaceutical Technology Faculty of Pharmacy Osaka Medical and Pharmaceutical University 4-20-1 Nasahara, Takatsuki Osaka 569-1094 Japan
3. Deuterium Science Research Unit Center for the Promotion of Interdisciplinary Education and Research Kyoto University Yoshida, Sakyo-ku Kyoto 606-8501 Japan