Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism-Reference-Cited by-同舟云学术

Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism

Published:2020-10-26 Issue:51 Volume:59 Page:23145-23153
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Nakou Ioanna T.¹,Jenner Matthew¹²^ORCID,Dashti Yousef¹³^ORCID,Romero‐Canelón Isolda⁴^ORCID,Masschelein Joleen¹⁵^ORCID,Mahenthiralingam Eshwar⁶^ORCID,Challis Gregory L.¹²⁷^ORCID

Affiliation:

1. Department of Chemistry University of Warwick Coventry CV4 7AL UK

2. Warwick Integrative Synthetic Biology Centre University of Warwick Coventry CV4 7AL UK

3. Current Address: The Centre for Bacterial Cell Biology, Biosciences Institute Medical School Newcastle University Newcastle upon Tyne NE2 4AX UK

4. Institute of Clinical Sciences School of Pharmacy University of Birmingham Birmingham B15 2TT UK

5. Current Address: Laboratory for Biomolecular Discovery &, Engineering VIB-KU Leuven Center for Microbiology Department of Biology KU Leuven 3001 Leuven Belgium

6. Organisms and Environment Division Cardiff School of Biosciences Cardiff University Cardiff CF10 3AT UK

7. Department of Biochemistry and Molecular Biology ARC Centre of Excellence for Innovations in Peptide and Protein Science Monash University Victoria 3800 Australia

Funder

Biotechnology and Biological Sciences Research Council

Medical Research Council

FP7 People: Marie-Curie Actions

Royal Society

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202009007

Reference43 articles.