Engineered Enzymes Enable Selective N ‐Alkylation of Pyrazoles With Simple Haloalkanes-Reference-Cited by-同舟云学术

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Engineered Enzymes Enable Selective N ‐Alkylation of Pyrazoles With Simple Haloalkanes

Published:2021-01-21 Issue:10 Volume:60 Page:5554-5560
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Bengel Ludwig L.¹^ORCID,Aberle Benjamin¹^ORCID,Egler‐Kemmerer Alexander‐N.¹^ORCID,Kienzle Samuel¹^ORCID,Hauer Bernhard¹^ORCID,Hammer Stephan C.²¹^ORCID

Affiliation:

1. Department of Technical Biochemistry Institute of Biochemistry and Technical Biochemistry University of Stuttgart Allmandring 31 70569 Stuttgart Germany

2. Faculty of Chemistry, Organic Chemistry and Biocatalysis Bielefeld University Universitätsstraße 25 33615 Bielefeld Germany

Funder

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202014239

Reference49 articles.

1. Catalytic Selective Synthesis

2. Katalytische selektive Synthese

3. C−H Bonds as Ubiquitous Functionality: A General Approach to Complex Arylated Pyrazoles via Sequential Regioselective C-Arylation and N-Alkylation Enabled by SEM-Group Transposition

4. Organic synthesis provides opportunities to transform drug discovery

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