Affiliation:
1. Key Laboratory for Advanced Materials Shanghai Key Laboratory of Functional Materials Chemistry Feringa Nobel Prize Scientist Joint Research Center Frontiers Science Center for Materiobiology & Dynamic Chemistry School of Chemistry & Molecular Engineering East China University of Science and Technology Shanghai 200237 P. R. China
2. School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen City Guangdong 518172 P. R. China
3. Department of Chemistry Faculty of Science Beni-Suef University Beni-Suef 62511 Egypt
Abstract
AbstractArtificially performing chemical reactions in living biosystems to attain various physiological aims remains an intriguing but very challenging task. In this study, the Schiff base reaction was conducted in cells using Sc(OTf)3 as a catalyst, enabling the in situ synthesis of a hollow covalent organic polymer (HCOP) without external stimuli. The reversible Schiff base reaction mediated intracellular Oswald ripening endows the HCOP with a spherical, hollow porous structure and a large specific surface area. The intracellularly generated HCOP reduced cellular motility by restraining actin polymerization, which consequently induced mitochondrial deactivation, apoptosis, and necroptosis. The presented intracellular synthesis system inspired by the Schiff base reaction has strong potential to regulate cell fate and biological functions, opening up a new strategic possibility for intervening in cellular behavior.
Funder
National Natural Science Foundation of China
Science and Technology Commission of Shanghai Municipality
Project 211
Fundamental Research Funds for the Central Universities
Subject
General Chemistry,Catalysis
Cited by
10 articles.
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