Affiliation:
1. Faculty of Pharmaceutical Sciences Hokkaido University Kita-ku, Sapporo 060-0812 Japan
2. Department of Chemistry Graduate School of Science Kyoto University Sakyo-ku, Kyoto 606-8502 Japan
Abstract
AbstractSulfondiimines are diaza‐analogues of sulfones with a chiral sulfur center. Compared to sulfones and sulfoximines, their synthesis and transformations have so far been studied to a lesser extent. Here, we report the enantioselective synthesis of 1,2‐benzothiazine 1‐imines, i.e., cyclic sulfondiimine derivatives from sulfondiimines and sulfoxonium ylides via C−H alkylation/cyclization reactions. The combination of [Ru(p‐cymene)Cl2]2 and a newly developed chiral spiro carboxylic acid is key to achieving high enantioselectivity.
Funder
Japan Society for the Promotion of Science
Subject
General Chemistry,Catalysis
Cited by
3 articles.
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