Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin**

Author:

Couturier Cédric1,Groß Sebastian2,von Tesmar Alexander2,Hoffmann Judith2,Deckarm Selina2,Fievet Anouchka3,Dubarry Nelly3,Taillier Thomas1,Pöverlein Christoph4,Stump Heike4,Kurz Michael4,Toti Luigi4,Haag Richter Sabine4,Schummer Dietmar5,Sizun Philippe4,Hoffmann Michael2,Prasad Awal Ram2,Zaburannyi Nestor2,Harmrolfs Kirsten2,Wink Joachim6,Lessoud Emilie1,Vermat Thierry1,Cazals Veronique1,Silve Sandra1,Bauer Armin4,Mourez Michael7,Fraisse Laurent8,Leroi‐Geissler Corinne1,Rey Astrid9,Versluys Stéphanie10,Bacqué Eric1,Müller Rolf2ORCID,Renard Stephane3

Affiliation:

1. Evotec 1541, avenue Marcel Mérieux 69280 Marcy L'Etoile France

2. Microbial Natural Products Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy at Saarland University Campus Building E8.1 66123 Saarbrücken Germany

3. Evotec 40 avenue Tony Garnier 69007 Lyon France

4. Sanofi 13, Quai Jules Guesde 94400 Vitry-sur-Seine France

5. Technische Hochschule Mittelhessen Wiesenstraße 14 35390 Gießen Germany

6. Mikrobielle Stammsammlung Helmholtz Centre for Infection Research (HZI) Inhoffenstraße 7 38124 Braunschweig Germany

7. Ecole d'Ingénieurs de Purpan 75 voie du Toec BP57611, 31076 Toulouse France

8. Drug for Neglected Diseases Initiative Chemin Camille-Vidart 15 1202 Geneva Switzerland

9. Charles River Laboratories 327 impasse du domaine rozier 69210 Saint-Germain-Nuelles France

10. Evotec 195, route d'Espagne 31000 Toulouse France

Publisher

Wiley

Subject

General Chemistry,Catalysis

Reference54 articles.

1. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

2. World Health Orgaization (WHO) “Global Antimicrobial Resistance Surveillance System (GLASS) Report. Early implementation” can be found underhttp://apps.who.int/iris/bitstream/handle/10665/259744/9789241513449-eng.pdf;jsessionid=97E045EBFE3B29F286CBA3EE8360F0D1?sequence=1 2018.

3. Resistance fighters

4. Antibacterial Activity of Eravacycline (TP-434), a Novel Fluorocycline, against Hospital and Community Pathogens

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