Discovery of a Novel Mycobacterial F‐ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines-Reference-Cited by-同舟云学术

Discovery of a Novel Mycobacterial F‐ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines

Published:2020-05-26 Issue:32 Volume:59 Page:13295-13304
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Hotra Adam¹²³^ORCID,Ragunathan Priya²^ORCID,Ng Pearly Shuyi⁴^ORCID,Seankongsuk Pattarakiat¹,Harikishore Amaravadhi¹²^ORCID,Sarathy Jickky Palmae⁵,Saw Wuan‐Geok²,Lakshmanan Umayal⁴,Sae‐Lao Patcharaporn¹,Kalia Nitin Pal⁶,Shin Joon²,Kalyanasundaram Revathy⁷^ORCID,Anbarasu Sivaraj⁷^ORCID,Parthasarathy Krupakar⁷^ORCID,Pradeep Chaudhari Namrata²,Makhija Harshyaa²,Dröge Peter²^ORCID,Poulsen Anders⁴,Tan Jocelyn Hui Ling⁴^ORCID,Pethe Kevin²⁶^ORCID,Dick Thomas⁵⁸^ORCID,Bates Roderick W.¹^ORCID,Grüber Gerhard²^ORCID

Affiliation:

1. School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link Singapore 637371 Republic of Singapore

2. School of Biological Sciences Nanyang Technological University 60 Nanyang Drive Singapore 637551 Republic of Singapore

3. Nanyang Institute of Technology in Health and Medicine Interdisciplinary Graduate School Nanyang Technological University Republic of Singapore

4. Experimental Drug Development Centre Agency for Science Technology and Research, A*STAR 10 Biopolis Road Singapore 138670 Republic of Singapore

5. Department of Microbiology and Immunology Yong Loo Lin School of Medicine National University of Singapore 14 Medical Drive Singapore 117599 Republic of Singapore

6. Lee Kong Chian School of Medicine Nanyang Technological University Experimental Medicine Building Republic of Singapore

7. Centre for Drug Discovery and Development Sathyabama Institute of Science and Technology Chennai 600119 India

8. Center for Discovery and Innovation Hackensack Meridian Health 340 Kingsland Street Nutley NJ 07110 USA

Funder

National Research Foundation Singapore

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202002546

Reference53 articles.

1. World Health Organization (2019) Global tuberculosis report 2019.https://www.who.int/tb/publications/global_report/en/.

3. G. M. Cook K. Hards C. Vilchèze T. Hartman M. Berney Microbiol. Spectr.2014 https://doi.org/10.1128/microbiolspec.MGM2-0015-2013;

4. The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

5. A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis

Cited by 33 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. N-Acyl phenothiazines as mycobacterial ATP synthase inhibitors: Rational design, synthesis and in vitro evaluation against drug sensitive, RR and MDR-TB;Bioorganic Chemistry;2024-10

2. Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587;Nature;2024-07-03

3. Switchable Site-Selective Benzanilide C(sp2)-H Bromination via Promoter Regulation;Molecules;2024-06-16

4. High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo;Journal of Biological Chemistry;2024-02

5. Mycobacterial F-ATP Synthase: From Structures to Target Sites to Inhibitors;Translational Research in Biomedical Sciences: Recent Progress and Future Prospects;2024