Switchable Site-Selective Benzanilide C(sp2)-H Bromination via Promoter Regulation-Reference-Cited by-同舟云学术

Switchable Site-Selective Benzanilide C(sp2)-H Bromination via Promoter Regulation

Published:2024-06-16 Issue:12 Volume:29 Page:2861
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Sun Yonghui¹^ORCID,He Qiyu¹^ORCID,Lv Xucheng¹^ORCID,Zhang Naizhen¹^ORCID,Yan Wei¹,Sun Jianghui¹,Zhuang Lili¹

Affiliation:

1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Abstract

Regioselective benzanilide bromination that generates either regioisomer from the same starting material is desirable. Herein, we develop switchable site-selective C(sp2)-H bromination by promoter regulation. This protocol leads to regiodivergent brominated benzanilide starting from the single substrate via selection of promoters. The protocol demonstrates excellent regioselectivity and good tolerance of functional groups with high yields. The utility effectiveness of this method has been well exemplified in the late-stage modification of biologically important molecules.

Funder

Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/12/2861/pdf

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