Alkali Carbonate Effects onN-(2-Hydroxyethyl)ureaCyclization: Application to a 2-Imidazolidinone Scale-Up-Reference-Cited by-同舟云学术

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Alkali Carbonate Effects onN-(2-Hydroxyethyl)ureaCyclization: Application to a 2-Imidazolidinone Scale-Up

Published:2013-07 Issue:4 Volume:50 Page:863-867
ISSN:0022-152X
Container-title:Journal of Heterocyclic Chemistry
language:en
Short-container-title:J. Heterocyclic Chem.

Author:

Kaldor Istvan¹,Spitzer Timothy¹,Duan Maosheng¹,Kazmierski Wieslaw M.¹,Boros Eric E.¹

Affiliation:

1. GlaxoSmithKline Research and Development; Five Moore Drive; Research Triangle Park; North Carolina; 27709

Publisher

Wiley

Subject

Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/jhet.1648/fullpdf

Reference23 articles.

1. Diastereoselective alkylation of chiral 2-imidazolidinone glycolates: asymmetric synthesis of α-hydroxy carboxylic acids

2. Stereoselective Synthesis of Quaternary Center Bearing Azetines and Their β-Amino Acid Derivatives

3. Optically Active Antifungal Azoles. XI. An Alternative Synthetic Route for 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (TAK-456) and Its Analog.

4. Optically Active Antifungal Azoles. XIII. Synthesis of Stereoisomers and Metabolites of 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (TAK-456).

5. Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives

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