Optically Active Antifungal Azoles. XIII. Synthesis of Stereoisomers and Metabolites of 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (TAK-456).

Author:

ICHIKAWA Takashi1,YAMADA Masami2,YAMAGUCHI Masashi3,KITAZAKI Tomoyuki2,MATSUSHITA Yoshihiro1,HIGASHIKAWA Keiko1,ITOH Katsumi1

Affiliation:

1. Medicinal Chemistry Research Laboratories I, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.

2. Medicinal Chemistry Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.

3. Drug Analysis & Pharmacokinetic Research Laboratories, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.

Publisher

Pharmaceutical Society of Japan

Subject

Drug Discovery,General Chemistry,General Medicine

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