Optically Active Antifungal Azoles. XIII. Synthesis of Stereoisomers and Metabolites of 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (TAK-456).-Reference-Cited by-同舟云学术

Optically Active Antifungal Azoles. XIII. Synthesis of Stereoisomers and Metabolites of 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (TAK-456).

Published:2001 Issue:9 Volume:49 Page:1110-1119
ISSN:0009-2363
Container-title:Chemical and Pharmaceutical Bulletin
language:en
Short-container-title:CHEMICAL & PHARMACEUTICAL BULLETIN

Author:

ICHIKAWA Takashi¹,YAMADA Masami²,YAMAGUCHI Masashi³,KITAZAKI Tomoyuki²,MATSUSHITA Yoshihiro¹,HIGASHIKAWA Keiko¹,ITOH Katsumi¹

Affiliation:

1. Medicinal Chemistry Research Laboratories I, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.

2. Medicinal Chemistry Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.

3. Drug Analysis & Pharmacokinetic Research Laboratories, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.

Publisher

Pharmaceutical Society of Japan

Subject

Drug Discovery,General Chemistry,General Medicine

Link

http://www.jstage.jst.go.jp/article/cpb/49/9/49_9_1110/_pdf

Reference25 articles.

1. Optically Active Antifungal Azoles. XII. Synthesis and Antifungal Activity of the Water-Soluble Prodrugs of 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone.

2. Optically Active Antifungal Azoles. X. Synthesis and Antifungal Activity of N-[4-(Azolyl)phenyl]- and N-[4-(Azolylmethyl)phenyl]-N'-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-azolones.

3. Optically Active Antifungal Azoles. XI. An Alternative Synthetic Route for 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (TAK-456) and Its Analog.

4. 3) a) Tsuchimori N., Hayashi R., Kitamoto N., Asai K., Kitazaki T., Iizawa Y., Itoh K., Okonogi K., Antimicrob. Agents Chemother., submitted

5. b) Hayashi R., Kitamoto N., Iizawa Y., Ichikawa T., Itoh K., Kitazaki T., Okonogi K., ibid., submitted.

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