Notum Deletion From Late‐Stage Skeletal Cells Increases Cortical Bone Formation and Potentiates Skeletal Effects of Sclerostin Inhibition-Reference-Cited by-同舟云学术

Notum Deletion From Late‐Stage Skeletal Cells Increases Cortical Bone Formation and Potentiates Skeletal Effects of Sclerostin Inhibition

Published:2021-07-23 Issue:12 Volume:36 Page:2413-2425
ISSN:0884-0431
Container-title:Journal of Bone and Mineral Research
language:en
Short-container-title:J of Bone & Mineral Res

Author:

Choi Roy B¹,Bullock Whitney A¹^ORCID,Hoggatt April M¹,Horan Daniel J¹,Pemberton Emily Z¹,Hong Jung Min²,Zhang Xinjun³⁴,He Xi³⁴,Robling Alexander G¹⁵⁶⁷^ORCID

Affiliation:

1. Department of Anatomy, Cell Biology, and Physiology Indiana University School of Medicine Indianapolis IN USA

2. Division of Biomedical and Applied Sciences Indiana University School of Dentistry Indianapolis IN USA

3. F. M. Kirby Neurobiology Center, Boston Children's Hospital Boston MA USA

4. Department of Neurology Harvard Medical School Boston MA USA

5. Department of Biomedical Engineering Indiana University–Purdue University at Indianapolis Indianapolis IN USA

6. Roudebush VA Medical Center Indianapolis IN USA

7. Indiana Center for Musculoskeletal Health Indianapolis IN USA

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

University of Missouri-Kansas City

Amgen

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbmr.4411

Reference58 articles.

1. WNT signaling in bone homeostasis and disease: from human mutations to treatments

2. Wnt signaling in disease and in development

3. Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

4. A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait

5. Bone Overgrowth-associated Mutations in the LRP4 Gene Impair Sclerostin Facilitator Function

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1. Notum regulates the cusp and root patterns in mouse molar;Scientific Reports;2024-06-13

2. NOTUM plays a bidirectionally modulatory role in the odontoblastic differentiation of human stem cells from the apical papilla through the WNT/β-catenin signaling pathway;Archives of Oral Biology;2024-04

3. Evidence for the major contribution of remodeling-based bone formation in sclerostin-deficient mice;Bone;2022-07

4. Overexpression of sonic hedgehog enhances the osteogenesis in rat ectomesenchymal stem cells;Cell and Tissue Banking;2022-02-11

5. Targeting Sclerostin and Dkk1 at Optimized Proportions of Low-Dose Antibody Achieves Similar Skeletal Benefits to Higher-Dose Sclerostin Targeting in the Mature Adult and Aged Skeleton;Aging and disease;2022