Chemotherapy for second-stage human African trypanosomiasis: drugs in use

Author:

Lutje Vittoria1,Probyn Katrin2,Seixas Jorge3,Bergman Hanna2,Villanueva Gemma2

Affiliation:

1. Department of Clinical Sciences; Liverpool School of Tropical Medicine; Liverpool UK

2. Cochrane Response; Cochrane; London UK

3. Institute of Hygiene and Tropical Medicine and Global Health and Tropical Medicine R&D Center; NOVA University; Lisbon Portugal

Publisher

Wiley

Subject

Pharmacology (medical)

Reference58 articles.

1. Follow-up abbreviated clinical study report DNDiFEX004 - fexinidazole. Efficacy and safety of fexinidazole compared to nifurtimox-eflornithine combination therapy (NECT) in patients with late-stage human African trypanosomiasis (HAT) due to T. b. gambiense: a pivotal, non-inferiority, randomised, open-label, multicentre study Data on file

2. European Medicines Agency Committee for Medicinal Products for Human Use Assessment report fexinidazole winthrop; 2018 www.ema.europa.eu/en/documents/medicine-outside-eu/fexinidazole-winthrop-assessment-report_en-0.pdf 

3. Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial;Mesu;Lancet,2018

4. Nifurtimox-eflornithine combination therapy for second-stage gambiense human African trypanosomiasis: Medecins Sans Frontieres experience in the Democratic Republic of the Congo;Alirol;Clinical Infectious Diseases,2013

5. Oral fexinidazole for human African trypanosomiasis;Chappuis;Lancet,2018

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