Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activ

Author:

Lyden Patrick1,Pryor Kent E.2,Coffey Christopher S.3,Cudkowicz Merit4,Conwit Robin5,Jadhav Ashutosh6,Sawyer Robert N.7,Claassen Jan8,Adeoye Opeolu9,Song Shlee1,Hannon Peter10,Rost Natalia S.4,Hinduja Archana11,Torbey Michel11,Lee Jin-Moo12,Benesch Curtis13,Rippee Michael14,Rymer Marilyn14,Froehler Michael T.15,Clarke Haley E.16,Johnson Mark17,Yankey Jon3,Magee Kim3,Qidwai Julie3,Levy Howard18,Mark Haacke E.19,Fawaz Miller19,Davis Thomas P.20,Toga Arthur W.21,Griffin John H.22,Zlokovic Berislav V.23,

Affiliation:

1. Cedars-Sinai Medical Center; Los Angeles CA

2. ZZ Biotech, LLC; Houston TX

3. The University of Iowa; Iowa City IA

4. Massachusetts General Hospital; Neurological Clinical Research Institute; Boston MA

5. National Institutes of Health; National Institute of Neurological Disorders and Stroke; Bethesda MD

6. University of Pittsburgh Medical School; Pittsburgh PA

7. State University of New York-University at Buffalo; Buffalo NY

8. Neurological Institute; Columbia University; New York NY

9. Department of Emergency Medicine; University of Cincinnati; Cincinnati OH

10. University of Utah; Salt Lake City UT

11. Ohio State University Medical Center; Columbus OH

12. Barnes-Jewish Hospital; St. Louis MO

13. University of Rochester Medical Center; Rochester NY

14. The University of Kansas Hospital; Kansas City KS

15. Cerebrovascular Program; Vanderbilt University Medical Center; Nashville TN

16. University of Virginia; Charlottesville VA

17. Southwestern Medical Center; University of Texas; Dallas TX

18. Consultant, ZZ Biotech, LLC

19. The MRI Institute for Biomedical Research; Bingham Farms, MI

20. Department of Medical Pharmacology, College of Medicine; University of Arizona; Tucson AZ

21. Laboratory of Neuro Imaging, Institute of Neuroimaging and Informatics, Keck School of Medicine; University of Southern California Los Angeles; Los Angeles CA

22. The Scripps Research Institute; La Jolla CA

23. Zilkha Neurogenetic Institute and Department of Physiology and Neuroscience, Keck School of Medicine; University of Southern California Los Angeles; Los Angeles CA

Funder

National Institute of Neurological Disorders and Stroke

Publisher

Wiley

Subject

Clinical Neurology,Neurology

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