3K3A–activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://www.nature.com/articles/nm.4154.pdf
Reference43 articles.
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2. Cheng, T. et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat. Med. 9, 338–342 (2003).
3. Cheng, T. et al. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat. Med. 12, 1278–1285 (2006).
4. Thiyagarajan, M., Fernández, J.A., Lane, S.M., Griffin, J.H. & Zlokovic, B.V. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J. Neurosci. 28, 12788–12797 (2008).
5. Wang, Y. et al. An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents. Stroke 43, 2444–2449 (2012).
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