A sensitive LC-MS/MS method for the simultaneous determination of amoxicillin and ambroxol in human plasma with segmental monitoring

Author:

Dong Xin1,Ding Li1,Cao Xiaomei2,Jiang Liyuan1,Zhong Shuisheng1

Affiliation:

1. Department of Pharmaceutical Analysis; China Pharmaceutical University; 24 Tongjiaxiang; Nanjing; 210009; China

2. Organization for State Drug Clinical Trial; Nanjing General Hospital of Nanjing Military Command; Nanjing; 210002; China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference27 articles.

1. Comparative bioavailability of 875 mg amoxicillin tablets in healthy human volunteers;Baglie;International Journal of Clinical Pharmacology and Therapeutics,2005

2. J. Determination of amoxycillin in human plasma by direct injection and coupled-column high-performance liquid chromatography;Cass;Journal of Chromatography. A,2003

3. Simple analysis of amoxycillin in plasma by high performance liquid chromatography with internal standardization and ultraviolet detection;Charles;Biomedical Chromatography,1993

4. Application and validation of a LC/fluorescence method for the determination of amoxicillin in sheep serum and tissue cage fluid;Delis;Journal of Pharmaceutical and Biomedical Analysis,2009

5. Influence of ambroxol on amoxicillin levels in bronchoalveolar lavage fluid;Gene;Arzneimittelforschung,1987

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