Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation-Reference-Cited by-同舟云学术

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Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation

Published:2020-01-23 Issue:4 Volume:117 Page:1063-1071
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnology and Bioengineering

Author:

Swope Nicole¹^ORCID,Chung Wai Keen²^ORCID,Cao Mingyan³,Motabar Dana²,Liu Dengfeng³,Ahuja Sanjeev⁴^ORCID,Handlogten Michael⁴^ORCID

Affiliation:

1. Department of Chemistry University of Virginia Charlottesville Virginia

2. Purification Process Sciences AstraZeneca Gaithersburg Maryland

3. Analytical Sciences AstraZeneca Gaithersburg Maryland

4. Cell Culture and Fermentation Sciences AstraZeneca Gaithersburg Maryland

Funder

Foundation for the National Institutes of Health

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27264

Reference33 articles.

1. Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease

2. Intrachain disulfide bond in the core hinge region of human IgG4

3. The making of bispecific antibodies

4. Alternatively folded states of an immunoglobulin

5. Characterization and analysis of scFv-IgG bispecific antibody size variants

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1. Engineering and physicochemical characterization of a novel, stable, symmetric bispecific antibody with dual target‐binding using a common light chain;Protein Science;2024-09-14

2. Decoupling Protein Concentration and Aggregate Content Using Diffusion and Water NMR;Analytical Chemistry;2024-06-29

3. Escherichia coli and Pichia pastoris : microbial cell-factory platform for full-length IgG production;Critical Reviews in Biotechnology;2024-05-26

4. Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins;Bioprocess and Biosystems Engineering;2024-04-23

5. Design and engineering of bispecific antibodies: insights and practical considerations;Frontiers in Bioengineering and Biotechnology;2024-01-25

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