Deletion of the carboxyl-terminal residue disrupts the amino-terminal folding, self-association, and thermal stability of an amphipathic antimicrobial peptide

Author:

Lee Chang-Shin1,Tung Wei-Cheng1,Lin Yu-Hsin1

Affiliation:

1. Department of Chemistry; Tamkang University; No.151 Yingzhuan Road, Tamsui District New Taipei City 25137 Taiwan China

Publisher

Wiley

Subject

Organic Chemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry,Structural Biology

Reference56 articles.

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2. Tsp: a tail-specific protease that selectively degrades proteins with nonpolar C termini;Silber;Proc. Natl. Acad. Sci. U. S. A.,1992

3. The ClpXP and ClpAP proteases degrade proteins with carboxyterminal peptide tails added by the SsrA-tagging system;Gottesman;Genes Dev.,1998

4. Polar residue tagging of transmembrane peptides;Melnyk;Biopolymers,2003

5. Deletion of a terminal residue disrupts oligomerization of a transmembrane α-helix;Ng;Biochem. Cell Biol.,2010

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