Determination of trimethylamine-N-oxide in combination withl-carnitine andγ-butyrobetaine in human plasma by UPLC/MS/MS

Author:

Grinberga Solveiga1,Dambrova Maija12,Latkovskis Gustavs345,Strele Ieva2,Konrade Ilze2,Hartmane Dace1,Sevostjanovs Eduards14,Liepinsh Edgars1,Pugovics Osvalds1

Affiliation:

1. Latvian Institute of Organic Synthesis; Riga Latvia

2. Riga Stradins University; Riga Latvia

3. Paul Stradins Clinical University Hospital; Riga Latvia

4. University of Latvia; Riga Latvia

5. Latvian Research Institute of Cardiology; Riga Latvia

Funder

Latvijas Zinatnes Padome

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference20 articles.

1. Ion suppression in mass spectrometry;Annesley;Clinical Chemistry,2003

2. Accumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis;Bain;Nephrology, Dialysis, Transplantation,2006

3. Risks and benefits of carnitine supplementation in diabetes;Dambrova;Experimental and Clinical Endocrinology and Diabetes,2015

4. Meldonium decreases the diet-increased plasma levels of trimethylamine N-oxide, a metabolite associated with atherosclerosis;Dambrova;Journal of Clinical Pharmacology,2013

5. l-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis;DiNicolantonio;Mayo Clinic Proceedings,2013

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