miRNA engineering of CHO cells facilitates production of difficult-to-express proteins and increases success in cell line development-Reference-Cited by-同舟云学术

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miRNA engineering of CHO cells facilitates production of difficult-to-express proteins and increases success in cell line development

Published:2017-04-18 Issue:7 Volume:114 Page:1495-1510
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnol. Bioeng.

Author:

Fischer Simon¹²^ORCID,Marquart Kim F.¹,Pieper Lisa A.³,Fieder Juergen¹,Gamer Martin¹,Gorr Ingo¹,Schulz Patrick²,Bradl Harald²

Affiliation:

1. Early Stage Bioprocess Development; Boehringer Ingelheim GmbH & Co. KG; Birkendorfer Strasse 65 88397 Biberach Germany

2. Cell Culture Development CMB; Boehringer Ingelheim GmbH & Co. KG; Biberach Germany

3. Institute of Cell Biology and Immunology; University of Stuttgart; Stuttgart Germany

Funder

Boehringer Ingelheim

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/bit.26280/fullpdf

Reference48 articles.

1. Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7;Barron;J Biotechnol,2011a

2. MicroRNAs: Tiny targets for engineering CHO cell phenotypes;Barron;Biotechnol Lett,2011b

3. Differential efficiency of expression of humanized antibodies in transient transfected mammalian cells;Bentley;Hybridoma,1998

4. Disassembly of polyethylenimine-DNA particles in vitro: Implications for polyethylenimine-mediated DNA delivery;Bertschinger;J Control Release,2006

5. Role of deregulated microRNAs in breast cancer progression using FFPE tissue;Chen;PLoS ONE,2013

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3. A systemic approach to identifying sequence frameworks that decrease mAb production in a transient Chinese hamster ovary cell expression system;Biotechnology Progress;2024-04-12

4. Stable overexpression of native and artificial miRNAs for the production of differentially fucosylated antibodies in CHO cells;Engineering in Life Sciences;2024-04

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